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Trends Microbiol. 2003 Feb;11(2):56-9.

The HIV-TSG101 interface: recent advances in a budding field.

Author information

1
Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-0460, USA. EFreed@nih.gov

Abstract

Efficient budding of HIV from the plasma membrane requires a small peptide motif, Pro-Thr/Ser-Ala-Pro (PTAP), located near the amino terminus of the p6 Gag protein. Studies from several laboratories have demonstrated that the ability of p6 to stimulate HIV budding requires a direct interaction between the PTAP motif and the host endosomal sorting protein TSG101. The structure of the PTAP-TSG101 binding site has recently been solved, providing valuable insights into this crucial protein-protein interaction.

PMID:
12598123
DOI:
10.1016/s0966-842x(02)00013-6
[Indexed for MEDLINE]

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