Send to

Choose Destination
See comment in PubMed Commons below
Life Sci. 2003 Mar 14;72(17):1909-18.

Prevention of neurotoxicity in hypoxic cortical neurons by the noble gas xenon.

Author information

University Hospital Charité, Clinic for Anesthesiology and Intensive Care, Experimental Anesthesiology, FH 31, Spandauer Damm 130, 14050 Berlin, Germany.


Hypoxia-induced neuronal damage and glutamate release were investigated in a N(2)- or in xenon-atmosphere for embryonic rat cortical neurons; cellular damage and glutamate over-release were observed in N(2)-treated cells whereas xenon protected the cells from the hypoxic insult. The protective effect of xenon was strongly reduced by pre-incubating neurons with the calcium-chelator BAPTA-AM indicating a role for calcium in this process. The results demonstrate (a) the neuroprotective properties of xenon, suggest (b) a relationship between the prevention of neurotransmitter release in a hypoxic situation and neuroprotection and present

[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center