Send to

Choose Destination
See comment in PubMed Commons below
Trends Plant Sci. 2003 Feb;8(2):83-9.

First glance at the plant APC/C, a highly conserved ubiquitin-protein ligase.

Author information

Institut de Biologie Moléculaire des Plantes du CNRS, 12, rue du Général Zimmer, 67084 Strasbourg Cédex, France.


The anaphase-promoting complex or cyclosome (APC/C) is a cell-cycle-regulated ubiquitin-protein ligase that has been extensively studied in both fungal and animal cells. Many APC/C protein targets have been identified, and their sequential degradation during the cell cycle is essential for chromatid separation and mitotic exit. APC/C-dependent ubiquitylation of proteins not involved in cell-cycle progression has also been documented in animal cells. By contrast, the plant APC/C's structure and functions remained unexplored until recently. Here, we discuss recent developments in this field and explore the Arabidopsis genome sequence to identify plant APC/C components. Details of the APC/C ubiquitylation pathway in Arabidopsis are also available on a website that will be regularly updated.

[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center