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Science. 2003 Feb 21;299(5610):1196-201.

Encoding pheromonal signals in the accessory olfactory bulb of behaving mice.

Author information

1
Howard Hughes Medical Institute and Department of Neurobiology, Duke University Medical Center, Durham, NC 27710, USA. luo@neuro.duke.edu

Abstract

Many mammalian species rely on pheromones-semiochemicals produced by other members of the same species-to communicate social status and reproductive readiness. To assess how the central nervous system integrates the complex repertoire of pheromones, we recorded from single neurons in the accessory olfactory bulb, a nucleus that processes pheromonal signals, of male mice engaged in natural behaviors. Neuronal firing was robustly modulated by physical contact with male and female conspecifics, with individual neurons activated selectively by specific combinations of the sex and strain of conspecifics. We infer that mammals encode social and reproductive information by integrating vomeronasal sensory activity specific to sex and genetic makeup.

PMID:
12595684
DOI:
10.1126/science.1082133
[Indexed for MEDLINE]
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