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Eur J Obstet Gynecol Reprod Biol. 2003 Mar 26;107(1):45-6.

Lack of anti-D in women at birth following antepartum immune globulin prophylaxis.

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Laboratory of Immunohaematology, Shaare Zedek Medical Center, Faculty of Health Sciences, Ben Gurion University of the Negev, Be'er Sheva, Jerusalem 91031, Israel.


Antepartum prophylaxis using Rh immune globulin suppresses maternal immunization to transplacental transfer of Rh-positive fetal cells, and, theoretically, to be effective, anti-D should be detectable until birth. We used a sensitive gel technique to quantitatively detect the serum concentration of anti-D at birth in 150 women who had received 300 microg of Rh immune globulin at 28 weeks gestation. Our method, which was sensitive enough to detect 20-25 microg, the recommended residual amount at birth, was positive in only 21% total, and in only 13% of women at term. Fifty-seven percent of women with premature births had above the recommended level of anti-D.

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