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J Allergy Clin Immunol. 2003 Feb;111(2 Suppl):S560-70.

11. Allergic and immunologic diseases of the skin.

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Dermatology Branch, Center for Cancer Research, National Cancer Institute, Building 10/Room 12N238, 10 Center Drive, Bethesda, MD 20892-1908, USA.


Many skin diseases have an inflammatory or immune component, and anti-inflammatory drugs comprise a major portion of a dermatologist's therapeutic armamentarium. Although causes of most of these diseases remain obscure, mechanisms of lesion formation and explanations for symptoms are increasingly well documented. These developments, coupled with the expected availability of novel selective immunomodulatory agents, herald a new era for immunodermatology. Patients with psoriasis, allergic contact dermatitis, atopic dermatitis, urticaria, and autoantibody-mediated blistering diseases are among those who are likely to benefit from advances in the understanding of disease pathogenesis and the emergence of immunotherapeutics.

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