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Biochem Biophys Res Commun. 2003 Feb 21;301(4):1062-8.

Inhibition of Epstein-Barr virus lytic cycle by (-)-epigallocatechin gallate.

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Department of Biology, Kaohsiung Medical University, 100, Shih-Chuan 1st Rd., 807, Kaohsiung, Taiwan.


(-)-Epigallocatechin gallate (EGCG), abundant in green tea, is a potent anti-microbial and anti-tumor compound. This investigation used immunoblot, flow cytometry, microarray, and indirect immunofluorescence analyses to show that at concentrations exceeding 50 microM, EGCG inhibits the expression of Epstein-Barr virus (EBV) lytic proteins, including Rta, Zta, and EA-D, but does not affect the expression of EBNA-1. Moreover, DNA microarray and transient transfection analyses demonstrated that EGCG blocks EBV lytic cycle by inhibiting the transcription of immediate-early genes, thus inhibiting the initiation of EBV lytic cascade.

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