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J Neurol Neurosurg Psychiatry. 2003 Mar;74(3):385-7.

Neuroleptic malignant syndrome in Kufs' disease.

Author information

1
Department of Psychiatry and Psychotherapy, Julius-Maximilians-University W├╝rzburg, Germany. a.reif@gmx.net

Abstract

A patient with adult neuronal ceroid lipofuscinosis (ANCL; Kufs' disease) is described in whom neuroleptic malignant syndrome occurred, initially presenting as catatonic syndrome. Comprehensive neuroimaging studies were conducted including FDG-PET, IBZM-SPECT, and beta-CIT-SPECT, electrophysiological examinations and an ex vivo contracture test exposing muscle biopsy specimens to neuroleptics. Collectively the results argued for an involvement of the muscle in neuroleptic malignant syndrome at least in ANCL.

PMID:
12588937
PMCID:
PMC1738314
[Indexed for MEDLINE]
Free PMC Article
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