[Neuroprotective effects of semax in MPTP-induced disturbances of brain dopamine system]

N G Levitskaia; E A Sebentsova; L A Andreeva; L Iu Alfeeva; A A Kamenskiĭ; N F Miasoedov

[Neuroprotective effects of semax in MPTP-induced disturbances of brain dopamine system]

Ross Fiziol Zh Im I M Sechenova. 2002 Nov;88(11):1369-77.

[Article in Russian]

Authors

N G Levitskaia¹, E A Sebentsova, L A Andreeva, L Iu Alfeeva, A A Kamenskiĭ, N F Miasoedov

Affiliation

¹ Institute of Molecular Genetics of the Russian Acad. Sci., 123182, Moscow' Moscow State University, 119899, Russia.

PMID: 12587264

Abstract

Effects of an ACTH (4-10) analogue Semax (MEHFPGP) on behaviour of white rats with MPTP-induced disturbances of brain DA-system have been studied. It was shown that MPTP administration (25 mg/kg) reduced motor activity and auhmented the anxiety level in rats. Semax administration (daily intranasal 0.2 mg/kg) attenuated behaviour disturbances induced by neurotoxin. The observed protective action of Semax in rats with MFTP-induced DA system disturbances may be due to both its modulating influence on the brain DA system and peptide neuroprotective effects.

Publication types

English Abstract

MeSH terms

Administration, Intranasal
Adrenocorticotropic Hormone / administration & dosage
Adrenocorticotropic Hormone / analogs & derivatives*
Adrenocorticotropic Hormone / pharmacology*
Animals
Behavior, Animal / drug effects*
Brain / drug effects*
Brain / metabolism
Disease Models, Animal
Dopamine / metabolism*
MPTP Poisoning / metabolism
MPTP Poisoning / physiopathology*
Male
Maze Learning / drug effects
Motor Activity / drug effects
Neuroprotective Agents / administration & dosage
Neuroprotective Agents / pharmacology*
Peptide Fragments / administration & dosage
Peptide Fragments / pharmacology*
Rats

Substances

Neuroprotective Agents
Peptide Fragments
ACTH (4-7), Pro-Gly-Pro-
Adrenocorticotropic Hormone
Dopamine