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Anal Chem. 2003 Feb 1;75(3):435-44.

Intensity-based statistical scorer for tandem mass spectrometry.

Author information

1
Compugen Limited, 72 Pinhas Rozen Street, Tel Aviv, 69512 Israel. moshe@compugen.co.il

Abstract

We describe a new statistical scorer for tandem mass spectrometry. The scorer is based on the probability that fragments with given chemical properties create measured intensity levels in the experimental spectrum. The scorer's parameters are computed using a fully automated procedure. Benchmarking the new scorer on a large set of experimental spectra, we show that it performs significantly better than the widely used cross-correlation scoring algorithm of Eng et al. (Eng, J. K; McKormack, A. L.; Yates, J. R. J. Am. Soc. Mass Spectrom. 1994, 5, 976-989.).

PMID:
12585468
DOI:
10.1021/ac0258913
[Indexed for MEDLINE]

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