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Chem Commun (Camb). 2003 Jan 21;(2):266-7.

Rapid reduction of pentavalent antimony by trypanothione: potential relevance to antimonial activation.

Author information

1
Department of Chemistry and Open Laboratory of Chemical Biology, University of Hong Kong, Pokfulam Road, Hong Kong, P. R. China.

Abstract

The dithiol trypanothione can reduce an antiparasitic pentavalent antimony agent to trivalent rapidly; this reduction process is both pH and temperature dependent and trypanothione may therefore play an important role in the activation of the drug.

PMID:
12585423
DOI:
10.1039/b210240d
[Indexed for MEDLINE]

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