Format

Send to

Choose Destination
Zhong Yao Cai. 2002 Apr;25(4):268-70.

[Protection of vascular endothelial cells from high glucose injury induced by quercetin].

[Article in Chinese]

Author information

1
College of Life Science, East China Normal University, ShangHai 200062.

Abstract

OBJECTIVE:

To evaluate the effects of quercetin on the high glucose-injured vascular endothelial cells (VECs).

METHODS:

Experiments were divided into control group, injured group and quercetin group. The cultured VECs were injured by high glucose. The proliferation of VECs was assessed by MTT assay. The amount of NO and lipid peroxidation (monitored as maloraldehyde, MDA) of VECs were assessed by fluorometric assay. The amount of lactate dehydrogenase (LDH) was assessed by spectrophotometric method.

RESULTS:

10(-2), 10(-3), 10(-4), 10(-5) mg/ml quercetin increased the proliferation of high glucose-injured VECs. 10(-2), 10(-3) mg/ml quercetin reduced LDH release and MDA production, increased NO release.

CONCLUSION:

Quercetin can protect cultured VECs from being injured by high glucose.

PMID:
12583178
[Indexed for MEDLINE]

Supplemental Content

Loading ...
Support Center