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Biochim Biophys Acta. 2003 Feb 17;1593(2-3):115-20.

Zyxin and paxillin proteins: focal adhesion plaque LIM domain proteins go nuclear.

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Department of Biology, Boston University, 5 Cummington Street, Boston, MA 02215-2406, USA.


Zyxin and paxillin are the prototypes of two related subfamilies of LIM domain proteins that are localized primarily at focal adhesion plaques. However, recent work has shown that zyxin/paxillin family proteins also shuttle through the nucleus. These proteins may enter the nucleus by association with other proteins, but are exported from the nucleus by means of intrinsic leucine-rich nuclear export sequences. Zyxin/paxillin proteins may regulate gene transcription by interaction with transcription factors. In some cases, misregulation of nuclear functions of zyxin/paxillin proteins appear to be associated with pathogenic effects.

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