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Curr Opin Struct Biol. 2003 Feb;13(1):56-63.

Eukaryotic translation initiation factors and regulators.

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1
Department of Biochemistry and McGill Cancer Centre, McGill University, 3655 Promenade Sir William Osler, Montreal, Quebec H3G 1Y6, Canada. nahum.sonenberg@mcgill.ca

Abstract

Significant progress has been made over the past several years on structural studies of the eukaryotic translation initiation factors that facilitate the assembly of a translation-competent ribosome at the initiation codon of an mRNA. These structural studies have revealed the repeated use of a set of common structural folds, highlighted the evolutionary conservation of the translation apparatus, and provided insight into the mechanism and regulation of cellular and viral protein synthesis.

PMID:
12581660
[Indexed for MEDLINE]
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