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Neurology. 2003 Feb 11;60(3):381-9.

Slowing Parkinson's disease progression: recent dopamine agonist trials.

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Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA.


In recent clinical trials, chronic treatment of patients with PD with pramipexole or ropinirole was associated with a slower decline of imaged striatal dopaminergic signal, compared to levodopa monotherapy. Although this could reflect slowed progression of PD, equally plausible is a pharmacologic effect on proteins that interact with the imaging radioligands. To date, there is no compelling evidence favoring dopamine agonists over levodopa; either is an appropriate choice for initial treatment of PD.

[Indexed for MEDLINE]

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