VBP-1 is necessary for morphogenesis in Caenorhabditis elegans

Harumi Ichimiya; Okio Hino; Yuji Kohara; Naoaki Ishii

VBP-1 is necessary for morphogenesis in Caenorhabditis elegans

Oncol Rep. 2003 Mar-Apr;10(2):293-5.

Authors

Harumi Ichimiya¹, Okio Hino, Yuji Kohara, Naoaki Ishii

Affiliation

¹ Department of Molecular Life Science, Tokai University School of Medicine, Bohseidai, Isehara, Kanagawa 259-1193, Japan.

PMID: 12579260

Abstract

VBP-1 has been isolated as a novel protein binding to the von Hippel-Lindau (VHL) tumor suppressor gene product. The fundamental function of the gene was examined in the nematode, Caenorhabditis elegans (C. elegans). The C. elegans VBP-1 gene was expressed in adults only in the gonads and was also expressed in early stage embryos. Double-stranded RNA interference (RNAi) against VBP-1 resulted in an arrest of embryogenesis at morula stages. This suggests that the VBP-1 product is necessary for morphogenesis.

Publication types

Comparative Study

MeSH terms

Amino Acid Sequence
Animals
Caenorhabditis elegans / embryology*
Caenorhabditis elegans / genetics
Caenorhabditis elegans Proteins / physiology*
Carrier Proteins / physiology*
Cytoskeletal Proteins
Gene Expression Regulation, Developmental / physiology*
Genes, Helminth / physiology
Humans
In Situ Hybridization
Ligases / genetics
Ligases / metabolism
Molecular Chaperones
Molecular Sequence Data
Morphogenesis*
RNA Interference
RNA Probes
RNA, Double-Stranded / genetics
Sequence Homology, Amino Acid
Tumor Suppressor Proteins*
Ubiquitin-Protein Ligases*
Von Hippel-Lindau Tumor Suppressor Protein

Substances

Caenorhabditis elegans Proteins
Carrier Proteins
Cytoskeletal Proteins
Molecular Chaperones
RNA Probes
RNA, Double-Stranded
Tumor Suppressor Proteins
VBP1 protein, human
Ubiquitin-Protein Ligases
Von Hippel-Lindau Tumor Suppressor Protein
Ligases
VHL protein, human

Associated data

GENBANK/Z81587
RefSeq/NM_003372