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Int J Immunopathol Pharmacol. 2003 Jan-Apr;16(1):1-8.

The role of complement and natural antibody in intestinal ischemia-reperfusion injury.

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Department of Surgery and Pathology, Harvard Medical School and Brigham and Women's Hospital, Boston, Massachusetts, USA.


Activation of the complement cascade is central to many types of injury. Ischemia-reperfusion is an important example of such an event. Using intestinal ischemia-reperfusion as a model, we have further elucidated the importance and mechanism of this activation. Of novel importance is the evidence that natural antibody is a trigger for these events via recognition of self-antigen. In this article, we review the role of natural antibody and complement in intestinal ischemia-reperfusion injury. It is hoped that this study will ultimately lead to better understanding of these important modulators and their role in this type of injury.

[Indexed for MEDLINE]

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