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Nat Genet. 2003 Mar;33(3):339-41. Epub 2003 Feb 10.

Coordination of the random asynchronous replication of autosomal loci.

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1
Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, Massachusetts 02142, USA.

Abstract

Random monoallelic expression and asynchronous replication define an unusual class of autosomal mammalian genes. We show that every cell has randomly chosen either the maternal or paternal copy of each given autosome pair, such that alleles of these genes scattered across the chosen chromosome replicate earlier than the alleles on the homologous chromosome. Thus, chromosome-pair non-equivalence, rather than being limited to X-chromosome inactivation, is a fundamental property of mouse chromosomes.

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PMID:
12577058
DOI:
10.1038/ng1102
[Indexed for MEDLINE]

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