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Cell Struct Funct. 2002 Dec;27(6):443-56.

Lysosome-related organelles: a view from immunity and pigmentation.

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1
Centre National de la Recherche Scientifique, UMR 144, Institut Curie, 75005 Paris, France. graposo@curie.fr

Abstract

Lysosomes are ubiquitous organelles that carry out essential household functions. Certain cell types, however, contain lysosome-related organelles with specialized functions. Their specialized functions are usually reflected by specific morphological and compositional features. A number of diseases that develop due to genetic mutations, pathogen exposure or cell transformation are characterized by dysfunctional lysosomes and/or lysosome-related organelles. In this review we highlight adaptations and malfunction of the endosomal/lysosomal system in normal and pathological situations with special focus on MHC class II compartments in antigen presenting cells and melanosomes in pigment cells.

PMID:
12576637
[Indexed for MEDLINE]
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