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Neuron. 2003 Feb 6;37(3):379-82.

Synaptic ribbon. Conveyor belt or safety belt?

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1
Department of Clinical Studies, New Bolton Center, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. thd@vet.upenn.edu

Abstract

The synaptic ribbon in neurons that release transmitter via graded potentials has been considered as a conveyor belt that actively moves vesicles toward their release sites. But evidence has accumulated to the contrary, and it now seems plausible that the ribbon serves instead as a safety belt to tether vesicles stably in mutual contact and thus facilitate multivesicular release by compound exocytosis.

PMID:
12575947
[Indexed for MEDLINE]
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