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Neuron. 2003 Feb 6;37(3):369-70.

Conservation and specialization. The role of the exocyst in neuronal exocytosis.

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1
Department of Biology, University of Pennsylvania, Philadelphia, PA 19104, USA.

Abstract

The exocyst is an octameric complex mediating vesicle targeting and tethering at the plasma membrane for exocytosis. The role of exocyst in nervous system is unclear. In this issue of Neuron, Murthy et al. provide important insights: defects in the exocyst inhibit neurite outgrowth and neuromuscular junction formation; however, synaptic transmission persists.

PMID:
12575943
[Indexed for MEDLINE]
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