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Surg Endosc. 2003 Apr;17(4):636-40. Epub 2003 Feb 10.

Randomized controlled trial of laparoscopic versus open colectomy for advanced colorectal cancer.

Author information

1
Department of Surgery, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan.

Abstract

BACKGROUND:

After confirming a favorable outcome of laparoscopic surgery for early colorectal cancer, we conducted a randomized controlled trial to compare short-term outcomes of laparoscopic and open colectomy for advanced colorectal cancer.

METHODS:

Fifty-nine patients with T2 or T3 colorectal cancer were randomized to undergo laparoscopic (n = 29) or open (n = 30) colectomy. Median follow-up was 20 months (range, 6-34 months).

RESULTS:

Operative time was longer (p <0.0001) and blood loss (p = 0.0034) and postoperative analgesic requirement were less in the laparoscopic group than in the open group. An earlier return of bowel motility and earlier discharge from the hospital (p = 0.0164) were observed after laparoscopic surgery. Serum C-reactive protein levels on postoperative days 1 (p <0.0001) and 4 (p = 0.0039) were lower in the laparoscopic group than in the open group. Postoperative complications did not differ between the two groups.

CONCLUSION:

Laparoscopic surgery for advanced colorectal cancer is feasible, with favorable short-term outcome.

PMID:
12574925
DOI:
10.1007/s00464-002-8516-4
[Indexed for MEDLINE]

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