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Biochim Biophys Acta. 2003 Feb 17;1619(3):235-8.

Functional and structural comparison of PXR and CAR.

Author information

1
Nuclear Receptor Discovery Research, GlaxoSmithKline, 5 Moore Drive, V116-1b, Research Triangle Park, NC 27709, USA. jtm36008@gsk.com

Abstract

The nuclear receptors pregnane X receptor (PXR, NR1I2) and constitutive active receptor (CAR, NR1I3) have both been proposed to function as xenosensors, but the details of their respective physiological roles are still being elucidated. We have contrasted these two receptors in a variety of experiments including gene expression assays, cell-based ligand profiling assays, and crystallographic/structural modeling analyses. These data highlight key differences between PXR and CAR.

PMID:
12573482
DOI:
10.1016/s0304-4165(02)00481-6
[Indexed for MEDLINE]

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