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Curr Opin Genet Dev. 2003 Feb;13(1):43-7.

RUNX transcription factors as key targets of TGF-beta superfamily signaling.

Author information

1
Institute of Molecular and Cell Biology and Oncology Research Institute, National University of Singapore, Singapore. itoy@imcb.nus.edu.sg

Abstract

The Runt domain transcription factors, RUNX1, RUNX2 and RUNX3, are integral components of signaling cascades mediated by both TGF-beta and bone morphogenetic proteins (BMPs) in several important biological systems. RUNX2 functions synergistically with Smad1 and Smad5 to regulate bone-specific genes when BMP induces osteogenesis. RUNX3, which has been mapped to locus 1p36, is a major tumor suppressor of gastric cancer and appears to be an important component of the TGF-beta-induced tumor suppressor pathway. A possible relationship between the TGF-beta-induced tumor-suppressor pathway and a postulated tumor suppressor gene on 1p36 must be examined.

PMID:
12573434
[Indexed for MEDLINE]

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