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Curr Opin Genet Dev. 2003 Feb;13(1):43-7.

RUNX transcription factors as key targets of TGF-beta superfamily signaling.

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Institute of Molecular and Cell Biology and Oncology Research Institute, National University of Singapore, Singapore.


The Runt domain transcription factors, RUNX1, RUNX2 and RUNX3, are integral components of signaling cascades mediated by both TGF-beta and bone morphogenetic proteins (BMPs) in several important biological systems. RUNX2 functions synergistically with Smad1 and Smad5 to regulate bone-specific genes when BMP induces osteogenesis. RUNX3, which has been mapped to locus 1p36, is a major tumor suppressor of gastric cancer and appears to be an important component of the TGF-beta-induced tumor suppressor pathway. A possible relationship between the TGF-beta-induced tumor-suppressor pathway and a postulated tumor suppressor gene on 1p36 must be examined.

[Indexed for MEDLINE]

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