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Curr Opin Genet Dev. 2003 Feb;13(1):14-9.

Genomic approaches to identification of tumour-susceptibility genes using mouse models.

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  • 1University of California, San Francisco Comprehensive Cancer Center, San Francisco, California 94143, USA.


Individual susceptibility to cancer in humans is determined by complex interactions between germline genetic variation and levels of exposure to environmental carcinogens or tumour promoters. Only a small fraction of cancer susceptibility is inherited in a Mendelian manner (high-penetrance familial cancer), and most tumours result from the combined effects of many gene-gene and gene-environment interactions. The sequencing of the mouse genome provides new approaches to one of the most challenging tasks of cancer genetics today.

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