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Curr Opin Genet Dev. 2003 Feb;13(1):14-9.

Genomic approaches to identification of tumour-susceptibility genes using mouse models.

Author information

  • 1University of California, San Francisco Comprehensive Cancer Center, San Francisco, California 94143, USA. jmao@cc.ucsf.edu

Abstract

Individual susceptibility to cancer in humans is determined by complex interactions between germline genetic variation and levels of exposure to environmental carcinogens or tumour promoters. Only a small fraction of cancer susceptibility is inherited in a Mendelian manner (high-penetrance familial cancer), and most tumours result from the combined effects of many gene-gene and gene-environment interactions. The sequencing of the mouse genome provides new approaches to one of the most challenging tasks of cancer genetics today.

PMID:
12573430
[PubMed - indexed for MEDLINE]
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