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Fertil Steril. 2003 Feb;79(2):439-41.

Successful pregnancies after combined pentoxifylline-tocopherol treatment in women with premature ovarian failure who are resistant to hormone replacement therapy.

Author information

1
Fertility Center, Department of Obstetrics and Assisted Reproductive Techniques, Institut Mutualiste Montsouris, Paris, France. helene.letur@imm.fr

Abstract

OBJECTIVE:

To determine whether treatment with combined pentoxifylline (PTX) and tocopherol (Vit.E) can improve uterine parameters in hormonal replacement therapy (HRT)-resistant women with premature ovarian failure (POF), for whom the outcome of assisted reproductive technology is usually negative. We previously reported that uterine radiation-induced fibrosis is reversible by combined PTX-Vit.E treatment.

DESIGN:

Case report.

SETTING:

Volunteer participants in an oocyte donation (OD) program in a French public hospital.

PATIENT(S):

Three women with POF (ages 36 +/- 2 years) using HRT exhibited uterine hormonoresistance, although they had high E(2) plasma levels. Their mean endometrial thickness was 4.9 mm, and they had an echogenic endometrium and thin uterine crosses.

INTERVENTION(S):

Between May 1998 and April 1999, treatment consisted of 800 mg of PTX combined with 1,000 IU of Vit.E daily for at least 9 months.

MAIN OUTCOME MEASURE(S):

Endometrial thickness, echogenicity, and pulsatility index of the uterine arteries, assessed by ultrasound and Doppler before and after treatment, and embryo implantation by IVF-OD.

RESULT(S):

PTX-Vit.E treatment was well tolerated and induced improvements, as mean edematous endometrial thickness increased to 7.4 mm, with nice uterine crosses. Three frozen-thawed ETs resulted in two viable pregnancies.

CONCLUSION(S):

In women with POF and uterine resistance to HRT, combined PTX-Vit.E reduces fibroatrophic uterine lesions and improves the uterine response to HRT, thus allowing embryo implantation and ongoing pregnancy.

PMID:
12568863
[Indexed for MEDLINE]

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