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J Am Chem Soc. 2003 Feb 12;125(6):1450-1.

Converting the sacrificial DNA repair protein N-ada into a catalytic methyl phosphotriester repair enzyme.

Author information

1
Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford St., Cambridge, Massachusetts 02138, USA.

Abstract

Mutation of the active-site residue Cys38 of N-Ada converts it from a sacrificial DNA repair protein to an enzyme that uses methanethiol as an external sacrificial reagent to repair DNA methyl phosphotriesters catalytically.

PMID:
12568584
DOI:
10.1021/ja028046a
[Indexed for MEDLINE]

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