Abstract
Crude extracts of the aerial parts of Marrubium vulgare show a potent in vitro inhibition of KCl-induced contraction of rat aorta. Bio-guided fractionations, spectroscopic analysis and chemical derivatization revealed the furanic labdane diterpenes marrubenol and marrubiin as the most active compounds.
Publication types
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Letter
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Aorta
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Diterpenes / chemistry
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Diterpenes / isolation & purification
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Diterpenes / pharmacology*
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Furans / chemistry
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Furans / isolation & purification
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Furans / pharmacology*
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In Vitro Techniques
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Magnetic Resonance Spectroscopy
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Marrubium / chemistry*
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Morocco
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Plants, Medicinal
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Potassium Chloride / pharmacology
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Rats
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Vasodilation / drug effects*
Substances
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Diterpenes
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Furans
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marrubenol
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Potassium Chloride
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marrubiin