Format

Send to

Choose Destination
Exp Eye Res. 2003 Feb;76(2):145-53.

Alpha-crystallin.

Author information

1
Jules Stein Eye Institute, UCLA School of Medicine, 100 Stein Plaza RM B168, Los Angeles, CA 90095-7008, USA. horwitz@jsei.ucla.edu

Abstract

Alpha A and alpha B-crystallins are a major protein component of the mammalian eye lens. Being a member of the small heat-shock protein family they possess chaperone-like function. The alpha-crystallins and especially alpha B is also found outside the lens having an extensive tissue distribution. Alpha B-crystallin is found to be over-expressed in many neurological diseases, and mutations in alpha A or B-crystallin can cause cataract and myopathy. This review deals with some of the unique properties of the alpha-crystallins emphasizing especially what we don't know about its function and structure.

PMID:
12565801
DOI:
10.1016/s0014-4835(02)00278-6
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center