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Nat Rev Immunol. 2003 Feb;3(2):169-76.

Innate immune sensing and its roots: the story of endotoxin.

Author information

  • 1The Scripps Research Institute, La Jolla, California 92037, USA. bruce@scripps.edu

Abstract

How does the host sense pathogens? Our present concepts grew directly from longstanding efforts to understand infectious disease: how microbes harm the host, what molecules are sensed and, ultimately, the nature of the receptors that the host uses. The discovery of the host sensors--the Toll-like receptors--was rooted in chemical, biological and genetic analyses that centred on a bacterial poison, termed endotoxin.

PMID:
12563300
DOI:
10.1038/nri1004
[PubMed - indexed for MEDLINE]
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