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Nat Rev Mol Cell Biol. 2003 Feb;4(2):117-26.

Tor signalling in bugs, brain and brawn.

Author information

1
Division of Biochemistry, Biozentrum, University of Basel, Klingelbergstrasse 70, CH-4056 Basel, Switzerland.

Erratum in

  • Nat Rev Mol Cell Biol. 2003 Mar;4(3):249.

Abstract

TOR--a highly conserved atypical protein kinase and the 'target of rapamycin', an immunosuppressant and anti-cancer drug--controls cell growth. TOR controls the growth of proliferating yeast, fly and mammalian cells in response to nutrients. Recent findings, however, indicate that TOR also controls the growth of non-proliferating cells, such as neurons and muscle cells. Furthermore, TOR, by associating with regulatory proteins and inhibiting phosphatases, controls the activity of multiphosphorylated effectors.

PMID:
12563289
DOI:
10.1038/nrm1018
[Indexed for MEDLINE]

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