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J Antimicrob Chemother. 2003 Feb;51(2):453-7.

A randomized comparative study to determine the effect of omeprazole on the peak serum concentration of itraconazole oral solution.

Author information

1
Division of Infectious Diseases and International Health, Duke University Medical Center, Box 3306 DUMC, Durham, NC 27710, USA. johns200@mc.duke.edu

Abstract

To determine the effect of omeprazole on peak serum concentrations (C(max)) of itraconazole oral solution (IOS), we carried out a randomized, open-label, prospective, crossover study. Fifteen healthy, non-pregnant adults received a single dose of IOS 400 mg on two occasions, at least 7 days apart, with omeprazole 40 mg nightly for 7 days before either IOS dose 1 or 2. C(max), time to C(max) (T(max)) and AUC(0-8) were determined for itraconazole and its active metabolite, hydroxyitraconazole, for each dose and compared. Omeprazole did not significantly affect the C(max), T(max) or AUC(0-8) of itraconazole or hydroxyitraconazole when administered as IOS.

PMID:
12562722
PMCID:
PMC4687480
DOI:
10.1093/jac/dkg089
[Indexed for MEDLINE]
Free PMC Article

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