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Cancer Cell. 2003 Jan;3(1):1-3.

Initiation of angiogenic Kaposi's sarcoma lesions.

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Viral Oncology Program, Sydney Kimmel Oncology Center, Bunting-Blaustein Building, 1650 Orleans Street, CRB 3M09, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.


A new mouse model reported in this issue of Cancer Cell implies that VEGF/KDR-mediated paracrine effects induced by the lytic cycle vGPCR signaling protein encoded by human Kaposi's sarcoma-associated herpesvirus (KSHV or HHV8) may be involved in promoting the proliferation of the KSHV latently infected spindle endothelial cells of Kaposi's sarcoma.

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