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Epilepsia. 2003 Feb;44(2):243-6.

Epilepsy-induced changes in signaling systems of human and rat postsynaptic densities.

Author information

1
Laboratorio de Neurociencias, Universidad de los , Santiago, Chile. uwyneken@uandes.cl

Abstract

PURPOSE:

To study seizure-induced changes in signaling proteins present in postsynaptic densities (PSDs) isolated from human epileptic neocortex and from rat cortex in which seizures were induced by injection of kainic acid.

METHODS:

We performed Western blot analysis of signaling proteins in PSDs isolated from cortical tissue.

RESULTS:

Seizures induce a strong upregulation of TrkB, the receptor for brain-derived neurotrophic factor (BDNF), whereas components of the N-methyl-d-aspartate (NMDA)-receptor complex are downregulated in both human and rat PSDs.

CONCLUSIONS:

These data show that long-term changes in PSD composition occur as a consequence of epileptic seizure activity.

PMID:
12558581
[Indexed for MEDLINE]
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