Format

Send to

Choose Destination
Anticancer Res. 2002 Nov-Dec;22(6C):3963-70.

Overexpression of early growth response-1 as a metastasis-regulatory factor in gastric cancer.

Author information

1
Department of Clinical Laboratory Medicine, Division of Laboratory Diagnosis, Sapporo Medical University School of Medicine, South-1, West-16, Chuo-ku, Sapporo 060-8543, Japan.

Abstract

BACKGROUND:

To investigate the potential role of a nuclear transcription factor, early growth response-1 (Egr-1), in formation and progression of gastric cancer, we compared its expression in gastric cancers with that in non-cancerous tissues.

MATERIALS AND METHODS:

Egr-1 mRNA expression was measured using TaqMan RT-PCR. The corresponding protein expression was examined immunohistochemically.

RESULTS:

Egr-1 mRNA expression was significantly higher in gastric cancer tissues than in normal mucosa (p < 0.0005). These differences were also reflected by protein product expression. Moreover, Egr-1 mRNA expression was higher in cases with metastasis to lymph nodes or remote organs. In cultured gastric cancer cells known to have a high metastatic potential, expression of this mRNA was higher than that of parental cells.

CONCLUSION:

It was suggested that Egr-1 has a significant role in carcinogenesis and in cancer progression, especially metastasis. Measurement of this mRNA should be useful for evaluation of the metastatic potential of gastric cancer.

PMID:
12553019
[Indexed for MEDLINE]

Supplemental Content

Loading ...
Support Center