Format

Send to

Choose Destination
See comment in PubMed Commons below
Neurology. 2003 Jan 28;60(2):337-40.

Toxic neuropathy in patients with pre-existing neuropathy.

Author information

1
Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA. vchaudh@jhmi.edu.

Abstract

The authors report significant worsening of a pre-existing neuropathy in six patients who received "non-toxic" dosages of known neurotoxic agents. Before treatment, baseline total neuropathy score (TNS) averaged 9.5 (range 0 to 19). After chemotherapy (Taxol [125 to 175 mg/m(2) x 4]; vincristine [2 to 5 mg]; cisplatin [40 mg/m(2) x 8]; and thalidomide [60 g]), the TNS averaged 22 (range 13 to 29). The authors conclude that functionally disabling toxic neuropathy can occur in patients with pre-existing neuropathy at standard doses.

PMID:
12552058
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire
    Loading ...
    Support Center