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Curr Opin Pharmacol. 2003 Feb;3(1):12-8.

GABA(A) receptor function and pharmacology in epilepsy and status epilepticus.

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University of Michigan, Ann Arbor, MI 48104-1687, USA.


GABA(A) (gamma-n-aminobutyric acid) receptor dysfunction has long been implicated in the development of epilepsy and status epilepticus. Recent advances have been made in understanding the cellular, pharmacological and genetic involvement of GABA(A) receptors in seizure disorders. In particular, genetic mutations found in GABA(A) receptor subunits strongly implicate the GABA(A) receptor in idiopathic generalised epilepsies.

[Indexed for MEDLINE]

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