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Neurol Sci. 2002 Sep;23 Suppl 2:S91-4.

Incidence of RBD and hallucination in patients affected by Parkinson's disease: 8-year follow-up.

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Department of Oncology and Neuroscience; Neurophysiopathology, G. D'Annunzio University, Ospedale Civile di Pescara, Via Fonte Romana, I-65124 Pescara, Italy.


We describe the 8-years follow-up of 80 patients affected by idiopathic, L-dopa-responsive Parkinson's disease. All patients were evaluated at baseline and during the follow-up with visual evoked potential, P300 event related potentials and polysomnography. The patients and their relatives compiled sleep and hallucination questionnaires. Statistical analysis was performed to evaluate if visual abnormalities, abnormal P300 recordings or sleep disturbances were linked to the development and hallucinations. Our results show that abnormal vision and abnormal P300 did not correlate with the incidence of hallucinations. However, the presence of REM sleep behavioral disorder (RBD) was significantly related to the development of hallucinations,independently of age, gender or duration of disease but dependent on the amount of dopaminoagonist treatment.

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