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Am J Obstet Gynecol. 2003 Jan;188(1):129-34.

Herpes simplex virus type II is not a cofactor to human papillomavirus in cancer of the uterine cervix.

Author information

1
Départements de Microbiologie-Infectiologie, Gynécologie-Obstétrique et de Pathologie, Centre Hospitalier de l'Université de Montréal, Université de Montréal, Montreal, Quebec, Canada.

Abstract

OBJECTIVE:

Cells that were cotransfected with herpes simplex virus-16 and the herpes simplex virus type 2 Xho -2 DNA induce tumors in nude mice. In a cross-sectional study, we investigated the role of herpes simplex virus type 2 as a cofactor to human papillomavirus in cervical cancer.

STUDY DESIGN:

Cervical cells that were obtained with an endocervical Cytobrush brush (Medscand) from 439 women (50 women with cancer lesions, 65 women with high-grade squamous intraepithelial lesions, 80 women with low-grade squamous intraepithelial lesions, 244 healthy subjects) and DNA that was extracted from 150 cervical cancer biopsy specimens were analyzed with polymerase chain reaction for herpes simplex virus type 2 Xho -2 and Bgl IIC transforming DNA sequences.

RESULTS:

All 439 cervical samples and 150 cervical cancer biopsy specimens tested negative for herpes simplex virus type 2 Xho -2 and Bgl IIC DNA by polymerase chain reaction. Overall, none of 200 samples (0%) from women with invasive cervical cancer contained herpes simplex virus type 2 Xho -2 or Bgl IIC DNA (95% CI, 0.0-1.8).

CONCLUSION:

Although herpes simplex virus type 2 Bgl IIN transforms epithelial cells in vitro, it was not detected in cervical cancer specimens.

PMID:
12548206
DOI:
10.1067/mob.2003.66
[Indexed for MEDLINE]

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