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Vaccine. 2003 Feb 14;21(9-10):836-42.

The adjuvant OM-174 induces both the migration and maturation of murine dendritic cells in vivo.

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  • 1Laboratory of Animal Physiology, Université Libre de Bruxelles, 6041, Gosselies, Belgium.

Abstract

The aim of this study was to test the capacity of the novel adjuvant OM-174, a lipid A analog, to induce the migration and the maturation of murine dendritic cells (DC) in vivo, a step which is considered as the initiation of the adaptive immune response. BALB/c mice were injected intravenously or subcutaneously with OM-174. The spleen and popliteal lymph nodes were harvested, and analyzed for DC localization and phenotype. The data presented here clearly show that, OM-174 induces the migration of DC from the periphery to the T cell areas of lymphoid organs, and their maturation into cells expressing high levels of MHC class II and co-stimulatory molecules, with a potency close to that of Escherichia coli lipopolysaccharide (LPS).

PMID:
12547591
[PubMed - indexed for MEDLINE]
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