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Lancet. 2003 Jan 18;361(9353):226-8.

Adiponectin and protection against type 2 diabetes mellitus.

Author information

1
Department of Nutrition, Endocrinology, and Metabolism, Benjamin Franklin Medical Centre, Free University Berlin, Germany. spranger@mail.dife.de

Erratum in

  • Lancet. 2002 Mar 22;361(9362):1060.

Abstract

Adiponectin is an adipocyte-derived peptide, which has anti-inflammatory and insulin-sensitising properties. We designed a nested case-control study to assess whether baseline adiponectin concentrations in plasma are independently associated with risk of type 2 diabetes. We found that adiponectin concentrations in plasma were lower among individuals who later developed type 2 diabetes than among controls (mean 5.34 microg/mL [SD 3.49] vs 6.87 microg/mL [4.58], p<0.0001). High concentrations of adiponectin were associated with a substantially reduced relative risk of type 2 diabetes after adjustment for age, sex, waist-to-hip ratio, body-mass index, smoking, exercise, alcohol consumption, education, and glycosylated haemoglobin A(1c) (odds ratio 4th vs 1st quartile 0.3 [95% CI 0.2-0.7], p=0.0051). We conclude that adiponectin is independently associated with a reduced risk of type 2 diabetes in apparently healthy individuals.

PMID:
12547549
DOI:
10.1016/S0140-6736(03)12255-6
[Indexed for MEDLINE]

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