Send to

Choose Destination
Trends Genet. 2003 Feb;19(2):65-8.

Gene conversion drives GC content evolution in mammalian histones.

Author information

CNRS UMR 5000-Génome, Populations, Interactions, Université Montpellier 2-CC63, Place E. Bataillon, 34095, Montpellier, France.


To examine the evolutionary influence of gene conversion on DNA base composition, I analysed an exhaustive dataset of histone paralogous genes from human and mouse. I show that those gene copies that belong to subfamilies of very similar sequences (presumably undergoing gene conversion) have a higher GC content than unique gene copies (presumably not undergoing gene conversion). Thus, it seems that gene conversion is a biased process that tends to increase the DNA GC content, a conclusion that has implications for the evolution of isochores in vertebrates.

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center