Format

Send to

Choose Destination
Curr Biol. 2003 Jan 21;13(2):R71-3.

Apoptosis: mitochondrial membrane permeabilization--the (w)hole story?

Author information

1
Centre National de la Recherche Scientifique, UMR1599, Institut Gustave Roussy, 39 rue Camille-Desmoulins, F-94805, Villejuif, France.

Abstract

One critical step of apoptosis is the release of mitochondrial proteins through the outer mitochondrial membrane. Recent work shows that two pro-apoptotic Bcl-2 family proteins, Bax and Bid, as well as the mitochondrion-specific lipid cardiolipin may cooperate in chemically defined liposomes to generate a protein-permeable conduit, relaunching the debate on the identity of the pore responsible for mitochondrial membrane permeabilization during apoptosis.

PMID:
12546810
DOI:
10.1016/s0960-9822(02)01433-1
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center