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Biochem Soc Trans. 2003 Feb;31(Pt 1):247-51.

Protein-protein interactions during mammalian DNA single-strand break repair.

Author information

1
Genome Damage and Stability Centre, University of Sussex, Science Park Road, Falmer, Brighton BN1 9RH, UK. k.w.caldecott@sussex.ac.uk

Abstract

The genetic stability of living cells is continually threatened by endogenous reactive oxygen species and other genotoxic molecules. Of particular threat are the thousands of single-strand breaks that arise in each cell every day. If left unrepaired, such breaks can give rise to potentially clastogenic or lethal chromosomal double-strand breaks. This article summarizes our current understanding of how mammalian cells detect and repair single strand breaks, and provides insights into novel polypeptide components of this process.

PMID:
12546695
DOI:
10.1042/
[Indexed for MEDLINE]
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