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Indian J Gastroenterol. 2002 Nov-Dec;21(6):216-8.

Effect of omeprazole on plasma zinc levels after oral zinc administration.

Author information

1
Department of Gastroenterology, Ege University School of Medicine, Bornova TR-35100, Izmir, Turkey. ozutemiz@med.ege.edu.tr

Abstract

BACKGROUND:

The intestines are the major site of zinc absorption and excretion. Reduced gastric acid secretion and elevated gastric pH is an important factor affecting intestinal mineral absorption.

METHODS:

Gastric pH and volume, and basal and maximal acid outputs were measured in 14 healthy volunteers. Plasma zinc levels were then measured at baseline and 1, 2, 3 and 4 hours after oral administration of 300 mg zinc sulfate. The experiment was repeated after omeprazole administration (60 mg/day orally) for 7 days.

RESULTS:

Omeprazole administration significantly increased fasting gastric pH (5.5 versus 2.4; p < 0.001). Mean basal gastric acid output (1.6 vs 8.0 mEq/h; p < 0.001) and maximal acid output (20.6 vs 106.6 mEq/h; p < 0.001) decreased after omeprazole administration. Zinc absorption decreased after omeprazole administration (141 [34] mg/dL/h) compared with pre-omeprazole values (245 [35]; p < 0.01).

CONCLUSION:

Suppression of gastric acid secretion by omeprazole reduces intestinal absorption of zinc.

PMID:
12546170
[Indexed for MEDLINE]
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