Format

Send to

Choose Destination
See comment in PubMed Commons below
Neuroreport. 2003 Jan 20;14(1):123-9.

Early intraneuronal Abeta deposition in the hippocampus of APP transgenic mice.

Author information

1
Department of Pathology, University of Washington, School of Medicine, Seattle, WA 98195-7490, USA.

Erratum in

  • Neuroreport. 2004 Aug 26;15(12):1993. LeBoeur, Renée C [corrected to LeBoeuf, Renée C].

Abstract

Increasing evidence suggests that intraneuronal amyloid-beta (Abeta) accumulation may be an early event in Alzheimer's disease (AD) pathogenesis. However direct in vivo evidence regarding initial Abeta seeding is missing. Using an APP transgenic mouse model, our sensitive immunocytochemical procedures revealed a novel intraneuronal Abeta deposition in the somas of hippocampal CA1/subiculum neurons far in advance of the occurrence of extracellular Abetaplaques. These deposits increased exponentially with age and were elevated approximately 4-fold (p < 0.001) by high fat/high cholesterol diet. Abeta40 and Abeta42 were the major constituents of these deposits and were co-localized with lysosomal markers. Our results are consistent with the notion that the earliest Abeta deposition occurs intraneuronally, prior to extracellular amyloid plaque formation.

[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments

    Supplemental Content

    Full text links

    Icon for Wolters Kluwer
    Loading ...
    Support Center