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J Pediatr Hematol Oncol. 2003 Jan;25(1):73-7.

A chemosensitive pediatric extraosseous osteosarcoma: case report and review of the literature.

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  • 1Departments of Hematology/ Oncology, St. Jude's Research Hospital, 332 N. Lauderdale Street, Memphis, TN 38105-2794, USA.


Osteosarcoma arising in soft tissues is exceedingly rare in children. The tumor most often affects older adults, involves the lower extremity, responds poorly to chemotherapy, and carries a grave prognosis. The authors describe a 12-year-old girl with an extraosseous osteosarcoma of the left sternocleidomastoid muscle with pulmonary metastases. The patient responded well to neoadjuvant chemotherapy and remains disease-free nearly 3 years after her initial diagnosis. The authors review available information about this disease in children and adults. Children with extraosseous osteosarcoma may have a more favorable response to treatment than adults; thus, a curative approach using combined modality therapy appears warranted.

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