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Curr Opin Lipidol. 2003 Feb;14(1):21-7.

Effects of phenolics on vascular endothelial function.

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1
Heart Centre, The Alfred Hospital and Baker Heart Research Institute, Melbourne, Victoria, Australia. s.duffy@alfred.org.au

Abstract

PURPOSE OF REVIEW:

There continues to be considerable interest in the concept that antioxidant therapy may reduce cardiovascular risk. Phenols have antioxidant properties and may be important micronutrients. Epidemiological studies have demonstrated a strong link between phenolic intake and reduced cardiovascular risk, but the mechanism of benefit has not been determined.

RECENT FINDINGS:

Recent evidence has emerged that a number of phenolic compounds, particularly flavonoids, reverse vascular endothelial dysfunction. The normal endothelium plays a critical role in regulating vascular function, and endothelial dysfunction is associated with increased cardiovascular risk. The present article reviews the links between phenolic intake, endothelial function and cardiovascular risk.

SUMMARY:

Endothelium-derived nitric oxide bioactivity appears to be increased by supplementation with a number of phenols, and this may explain some of the favourable effects of high phenolic intake seen in epidemiological studies.

[Indexed for MEDLINE]
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