Association between human leukocyte antigen polymorphism and human papillomavirus 16-positive vulval intraepithelial neoplasia in British women

Cancer Res. 2003 Jan 15;63(2):400-3.

Abstract

Polymorphisms in human leukocyte antigen (HLA) genes have been implicated in the risk for developing human papillomavirus (HPV)-associated cervical neoplasia. By comparison with local cadaver controls typed for HLA class I (n = 946) and II (n = 144) antigens, HPV-16-positive high grade vulval intraepithelial neoplasia patients (n = 42) showed significantly different frequencies of HLA-A2 [odds ratio (OR), 2.1; confidence interval (CI), 1.4-3.9], HLA-B7 (OR, 2.6; CI, 1.4-4.7), HLA-DRB1*01(01/02/04) (OR, 0.1; CI, 0.03-0.5), HLA-DRB1*11 (OR, 3.3; CI, 1.4-7.1), HLA-DRB1*13 (OR, 0), HLA-DQB1*05 (OR, 0.2; CI, 0.05-0.6), and HLA-DQB1*03032 (OR, 4.6; CI, 1.5-14.0). With the exception of HLA-B7 and HLA-DRB1*11, these significant differences were also seen comparative to local HPV-16-positive cervical carcinoma patients (n = 114), suggesting a specific immunogenetic contribution that is independent of HPV-16 infection in high-grade vulval intraepithelial neoplasia. Such factors are important to the development of HPV vaccines for treatment of cervical and vulval neoplasia.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biopsy
  • Female
  • HLA-A Antigens / genetics*
  • HLA-DR Antigens / genetics*
  • Humans
  • Papillomaviridae / classification*
  • Papillomavirus Infections / genetics
  • Papillomavirus Infections / immunology*
  • Papillomavirus Infections / pathology
  • Polymorphism, Genetic
  • Tumor Virus Infections / genetics
  • Tumor Virus Infections / immunology*
  • Tumor Virus Infections / pathology
  • Vulvar Neoplasms / genetics
  • Vulvar Neoplasms / immunology*
  • Vulvar Neoplasms / pathology
  • Vulvar Neoplasms / virology*

Substances

  • HLA-A Antigens
  • HLA-DR Antigens