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Am J Med. 2003 Jan;114(1):10-4.

The risk of osteoporosis in Caucasian men and women with obstructive airways disease.

Author information

1
Division of Pulmonary Medicine, University of Alberta, Edmonton, Alberta, Canada. don.sin@ualberta.ca

Abstract

PURPOSE:

Because patients with obstructive airways disease may be susceptible to osteoporosis, we sought to determine the association between airflow obstruction and osteoporosis.

SUBJECTS AND METHODS:

We analyzed data from Caucasian participants (n = 9502) in the Third National Health and Nutrition Examination Survey, conducted in the United States between 1988 and 1994. We used data from dual-energy x-ray absorptiometry measurements of the total femur to determine whether a study participant had osteoporosis (defined as total bone mineral density values < or =2.5 SD below the corresponding mean values from young, healthy participants). We calculated the odds ratio (OR) for osteoporosis in four lung function categories: none, mild, moderate, and severe airflow obstruction.

RESULTS:

Overall, airflow obstruction was associated with increased odds of osteoporosis compared with without airflow obstruction (OR = 1.9; 95% confidence interval [CI]: 1.4 to 2.5). Participants with severe airflow obstruction were at especially increased risk (OR = 2.4; 95% CI: 1.3 to 4.4). Moderate but not mild airflow obstruction was also associated with osteoporosis.

CONCLUSION:

Airflow obstruction was an important risk factor for osteoporosis in the study population. These data highlight the importance of measuring bone mineral density in those with moderate-to-severe airflow obstruction for the detection and prevention of osteoporosis-related morbidity.

PMID:
12543283
DOI:
10.1016/s0002-9343(02)01297-4
[Indexed for MEDLINE]

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